Nimesulide is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer). It blocks the release of certain chemical messengers in the brain that are responsible for pain and fever. Phenylephrine is a nasal decongestant which narrows the small blood vessels providing relief from congestion or stuffiness in the nose. Caffeine is a stimulant which works by blocking the action of certain natural substances (adenosine and phosphodiesterase). Nimesulide & Paracetamol is a combination of two medicines: Nimesulide and Paracetamol. It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling). Nimesulide & Paracetamol is a combination of two medicines: Nimesulide and Paracetamol. It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).